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Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis.

Identifieur interne : 002970 ( Main/Exploration ); précédent : 002969; suivant : 002971

Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis.

Auteurs : Rik Ossenkoppele ; Willemijn J. Jansen [Pays-Bas] ; Gil D. Rabinovici [États-Unis] ; Dirk L. Knol [Pays-Bas] ; Wiesje M. Van Der Flier [Pays-Bas] ; Bart N M. Van Berckel [Pays-Bas] ; Philip Scheltens [Pays-Bas] ; Pieter Jelle Visser ; Sander C J. Verfaillie [Pays-Bas] ; Marissa D. Zwan [Pays-Bas] ; Sofie M. Adriaanse [Pays-Bas] ; Adriaan A. Lammertsma [Pays-Bas] ; Frederik Barkhof [Pays-Bas] ; William J. Jagust [États-Unis] ; Bruce L. Miller [États-Unis] ; Howard J. Rosen [États-Unis] ; Susan M. Landau [États-Unis] ; Victor L. Villemagne [Australie] ; Christopher C. Rowe [Australie] ; Dong Y. Lee [Corée du Sud] ; Duk L. Na [Corée du Sud] ; Sang W. Seo [Corée du Sud] ; Marie Sarazin [France] ; Catherine M. Roe [États-Unis] ; Osama Sabri [Allemagne] ; Henryk Barthel [Allemagne] ; Norman Koglin [Allemagne] ; John Hodges [Australie] ; Cristian E. Leyton [Australie] ; Rik Vandenberghe [Belgique] ; Koen Van Laere [Belgique] ; Alexander Drzezga [Allemagne] ; Stefan Forster [Allemagne] ; Timo Grimmer [Allemagne] ; Pascual Sánchez-Juan [Espagne] ; Jose M. Carril [Espagne] ; Vincent Mok [République populaire de Chine] ; Vincent Camus [France] ; William E. Klunk [États-Unis] ; Ann D. Cohen [États-Unis] ; Philipp T. Meyer [Allemagne] ; Sabine Hellwig [Allemagne] ; Andrew Newberg [États-Unis] ; Kristian S. Frederiksen [Danemark] ; Adam S. Fleisher [États-Unis] ; Mark A. Mintun [États-Unis] ; David A. Wolk [États-Unis] ; Agneta Nordberg [Suède] ; Juha O. Rinne [Finlande] ; Gaël Chételat [France] ; Alberto Lleo [Espagne] ; Rafael Blesa [Espagne] ; Juan Fortea [Espagne] ; Karine Madsen [Allemagne] ; Karen M. Rodrigue ; David J. Brooks [Royaume-Uni]

Source :

RBID : pubmed:25988463

Descripteurs français

English descriptors

Abstract

Amyloid-β positron emission tomography (PET) imaging allows in vivo detection of fibrillar plaques, a core neuropathological feature of Alzheimer disease (AD). Its diagnostic utility is still unclear because amyloid plaques also occur in patients with non-AD dementia.

DOI: 10.1001/jama.2015.4669
PubMed: 25988463


Affiliations:


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Le document en format XML

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<name sortKey="Ossenkoppele, Rik" sort="Ossenkoppele, Rik" uniqKey="Ossenkoppele R" first="Rik" last="Ossenkoppele">Rik Ossenkoppele</name>
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<name sortKey="Barkhof, Frederik" sort="Barkhof, Frederik" uniqKey="Barkhof F" first="Frederik" last="Barkhof">Frederik Barkhof</name>
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<nlm:affiliation>Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam</wicri:regionArea>
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<settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
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</affiliation>
</author>
<author>
<name sortKey="Jagust, William J" sort="Jagust, William J" uniqKey="Jagust W" first="William J" last="Jagust">William J. Jagust</name>
<affiliation wicri:level="3">
<nlm:affiliation>Helen Wills Neuroscience Institute, University of California, Berkeley7Lawrence Berkeley National Laboratory, University of California, Berkeley.</nlm:affiliation>
<country>États-Unis</country>
<placeName>
<settlement type="city">Berkeley (Californie)</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>Helen Wills Neuroscience Institute, University of California, Berkeley7Lawrence Berkeley National Laboratory, University of California</wicri:orgArea>
</affiliation>
</author>
<author>
<name sortKey="Miller, Bruce L" sort="Miller, Bruce L" uniqKey="Miller B" first="Bruce L" last="Miller">Bruce L. Miller</name>
<affiliation wicri:level="3">
<nlm:affiliation>Memory and Aging Center, University of California, San Francisco.</nlm:affiliation>
<country>États-Unis</country>
<placeName>
<settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>Memory and Aging Center, University of California</wicri:orgArea>
</affiliation>
</author>
<author>
<name sortKey="Rosen, Howard J" sort="Rosen, Howard J" uniqKey="Rosen H" first="Howard J" last="Rosen">Howard J. Rosen</name>
<affiliation wicri:level="3">
<nlm:affiliation>Memory and Aging Center, University of California, San Francisco.</nlm:affiliation>
<country>États-Unis</country>
<placeName>
<settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>Memory and Aging Center, University of California</wicri:orgArea>
</affiliation>
</author>
<author>
<name sortKey="Landau, Susan M" sort="Landau, Susan M" uniqKey="Landau S" first="Susan M" last="Landau">Susan M. Landau</name>
<affiliation wicri:level="3">
<nlm:affiliation>Helen Wills Neuroscience Institute, University of California, Berkeley7Lawrence Berkeley National Laboratory, University of California, Berkeley.</nlm:affiliation>
<country>États-Unis</country>
<placeName>
<settlement type="city">Berkeley (Californie)</settlement>
<region type="state">Californie</region>
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<wicri:orgArea>Helen Wills Neuroscience Institute, University of California, Berkeley7Lawrence Berkeley National Laboratory, University of California</wicri:orgArea>
</affiliation>
</author>
<author>
<name sortKey="Villemagne, Victor L" sort="Villemagne, Victor L" uniqKey="Villemagne V" first="Victor L" last="Villemagne">Victor L. Villemagne</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne</wicri:regionArea>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Rowe, Christopher C" sort="Rowe, Christopher C" uniqKey="Rowe C" first="Christopher C" last="Rowe">Christopher C. Rowe</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne</wicri:regionArea>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lee, Dong Y" sort="Lee, Dong Y" uniqKey="Lee D" first="Dong Y" last="Lee">Dong Y. Lee</name>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Neuropsychiatry, College of Medicine, Seoul National University, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Neuropsychiatry, College of Medicine, Seoul National University</wicri:regionArea>
<placeName>
<settlement type="city">Séoul</settlement>
</placeName>
<orgName type="university">Université nationale de Séoul</orgName>
</affiliation>
</author>
<author>
<name sortKey="Na, Duk L" sort="Na, Duk L" uniqKey="Na D" first="Duk L" last="Na">Duk L. Na</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Neurology, Sungkyunkwan University, Seoul, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Neurology, Sungkyunkwan University, Seoul</wicri:regionArea>
<placeName>
<settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Seo, Sang W" sort="Seo, Sang W" uniqKey="Seo S" first="Sang W" last="Seo">Sang W. Seo</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Neurology, Sungkyunkwan University, Seoul, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Neurology, Sungkyunkwan University, Seoul</wicri:regionArea>
<placeName>
<settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Sarazin, Marie" sort="Sarazin, Marie" uniqKey="Sarazin M" first="Marie" last="Sarazin">Marie Sarazin</name>
<affiliation wicri:level="4">
<nlm:affiliation>Neurologie de la Mémoire et du Langage, Sorbonne Paris Cité, INSERM UMR S894, Centre Hospitalier Sainte Anne, Université Paris Descartes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Neurologie de la Mémoire et du Langage, Sorbonne Paris Cité, INSERM UMR S894, Centre Hospitalier Sainte Anne, Université Paris Descartes</wicri:regionArea>
<wicri:noRegion>Université Paris Descartes</wicri:noRegion>
<placeName>
<settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="university">Université Paris-Descartes</orgName>
<orgName type="institution" wicri:auto="newGroup">Sorbonne Paris Cité</orgName>
</affiliation>
</author>
<author>
<name sortKey="Roe, Catherine M" sort="Roe, Catherine M" uniqKey="Roe C" first="Catherine M" last="Roe">Catherine M. Roe</name>
<affiliation wicri:level="2">
<nlm:affiliation>Department of Neurology, Knight Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, Missouri.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Department of Neurology, Knight Alzheimer Disease Research Center, Washington University School of Medicine, St Louis</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Sabri, Osama" sort="Sabri, Osama" uniqKey="Sabri O" first="Osama" last="Sabri">Osama Sabri</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Nuclear Medicine, University of Leipzig, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Nuclear Medicine, University of Leipzig</wicri:regionArea>
<wicri:noRegion>University of Leipzig</wicri:noRegion>
<wicri:noRegion>University of Leipzig</wicri:noRegion>
<wicri:noRegion>University of Leipzig</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Barthel, Henryk" sort="Barthel, Henryk" uniqKey="Barthel H" first="Henryk" last="Barthel">Henryk Barthel</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Nuclear Medicine, University of Leipzig, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Nuclear Medicine, University of Leipzig</wicri:regionArea>
<wicri:noRegion>University of Leipzig</wicri:noRegion>
<wicri:noRegion>University of Leipzig</wicri:noRegion>
<wicri:noRegion>University of Leipzig</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Koglin, Norman" sort="Koglin, Norman" uniqKey="Koglin N" first="Norman" last="Koglin">Norman Koglin</name>
<affiliation wicri:level="3">
<nlm:affiliation>Piramal Imaging, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Piramal Imaging, Berlin</wicri:regionArea>
<placeName>
<region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hodges, John" sort="Hodges, John" uniqKey="Hodges J" first="John" last="Hodges">John Hodges</name>
<affiliation wicri:level="3">
<nlm:affiliation>Neuroscience Research Australia, Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Neuroscience Research Australia, Sydney</wicri:regionArea>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Leyton, Cristian E" sort="Leyton, Cristian E" uniqKey="Leyton C" first="Cristian E" last="Leyton">Cristian E. Leyton</name>
<affiliation wicri:level="3">
<nlm:affiliation>Neuroscience Research Australia, Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Neuroscience Research Australia, Sydney</wicri:regionArea>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Vandenberghe, Rik" sort="Vandenberghe, Rik" uniqKey="Vandenberghe R" first="Rik" last="Vandenberghe">Rik Vandenberghe</name>
<affiliation wicri:level="4">
<nlm:affiliation>Laboratory for Cognitive Neurology and Alzheimer Research Center, Katholieke Universiteit Leuven, Catholic University Leuven, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory for Cognitive Neurology and Alzheimer Research Center, Katholieke Universiteit Leuven, Catholic University Leuven</wicri:regionArea>
<orgName type="university">Katholieke Universiteit Leuven</orgName>
<placeName>
<settlement type="city">Louvain</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province du Brabant flamand</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Van Laere, Koen" sort="Van Laere, Koen" uniqKey="Van Laere K" first="Koen" last="Van Laere">Koen Van Laere</name>
<affiliation wicri:level="4">
<nlm:affiliation>Laboratory for Cognitive Neurology and Alzheimer Research Center, Katholieke Universiteit Leuven, Catholic University Leuven, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory for Cognitive Neurology and Alzheimer Research Center, Katholieke Universiteit Leuven, Catholic University Leuven</wicri:regionArea>
<orgName type="university">Katholieke Universiteit Leuven</orgName>
<placeName>
<settlement type="city">Louvain</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province du Brabant flamand</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Drzezga, Alexander" sort="Drzezga, Alexander" uniqKey="Drzezga A" first="Alexander" last="Drzezga">Alexander Drzezga</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Nuclear Medicine, University of Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Nuclear Medicine, University of Cologne</wicri:regionArea>
<wicri:noRegion>University of Cologne</wicri:noRegion>
<wicri:noRegion>University of Cologne</wicri:noRegion>
<wicri:noRegion>University of Cologne</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Forster, Stefan" sort="Forster, Stefan" uniqKey="Forster S" first="Stefan" last="Forster">Stefan Forster</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Nuclear Medicine, Technische Universitaet Muenchen, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Nuclear Medicine, Technische Universitaet Muenchen, Munich</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Grimmer, Timo" sort="Grimmer, Timo" uniqKey="Grimmer T" first="Timo" last="Grimmer">Timo Grimmer</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technische Universitaet Muenchen, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technische Universitaet Muenchen, Munich</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Sanchez Juan, Pascual" sort="Sanchez Juan, Pascual" uniqKey="Sanchez Juan P" first="Pascual" last="Sánchez-Juan">Pascual Sánchez-Juan</name>
<affiliation wicri:level="1">
<nlm:affiliation>IFIMAV and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Marqués de Valdecilla University Hospital, Cantabria, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>IFIMAV and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Marqués de Valdecilla University Hospital, Cantabria</wicri:regionArea>
<wicri:noRegion>Cantabria</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Carril, Jose M" sort="Carril, Jose M" uniqKey="Carril J" first="Jose M" last="Carril">Jose M. Carril</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Nuclear Medicine, Marqués de Valdecilla University Hospital, University of Cantabria, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Nuclear Medicine, Marqués de Valdecilla University Hospital, University of Cantabria</wicri:regionArea>
<wicri:noRegion>University of Cantabria</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mok, Vincent" sort="Mok, Vincent" uniqKey="Mok V" first="Vincent" last="Mok">Vincent Mok</name>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName>
<settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Camus, Vincent" sort="Camus, Vincent" uniqKey="Camus V" first="Vincent" last="Camus">Vincent Camus</name>
<affiliation wicri:level="1">
<nlm:affiliation>INSERM U930 and Université François Rabelais de Tours, Centre Hospitalier Régional Universitaire Hôpitaux de Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U930 and Université François Rabelais de Tours, Centre Hospitalier Régional Universitaire Hôpitaux de Tours</wicri:regionArea>
<wicri:noRegion>Centre Hospitalier Régional Universitaire Hôpitaux de Tours</wicri:noRegion>
<wicri:noRegion>Centre Hospitalier Régional Universitaire Hôpitaux de Tours</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Klunk, William E" sort="Klunk, William E" uniqKey="Klunk W" first="William E" last="Klunk">William E. Klunk</name>
<affiliation wicri:level="2">
<nlm:affiliation>Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Cohen, Ann D" sort="Cohen, Ann D" uniqKey="Cohen A" first="Ann D" last="Cohen">Ann D. Cohen</name>
<affiliation wicri:level="2">
<nlm:affiliation>Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Meyer, Philipp T" sort="Meyer, Philipp T" uniqKey="Meyer P" first="Philipp T" last="Meyer">Philipp T. Meyer</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Nuclear Medicine, University Hospital Freiburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Nuclear Medicine, University Hospital Freiburg</wicri:regionArea>
<wicri:noRegion>University Hospital Freiburg</wicri:noRegion>
<wicri:noRegion>University Hospital Freiburg</wicri:noRegion>
<wicri:noRegion>University Hospital Freiburg</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hellwig, Sabine" sort="Hellwig, Sabine" uniqKey="Hellwig S" first="Sabine" last="Hellwig">Sabine Hellwig</name>
<affiliation wicri:level="1">
<nlm:affiliation>Centre for Geriatrics and Gerontology, University Hospital Freiburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Centre for Geriatrics and Gerontology, University Hospital Freiburg</wicri:regionArea>
<wicri:noRegion>University Hospital Freiburg</wicri:noRegion>
<wicri:noRegion>University Hospital Freiburg</wicri:noRegion>
<wicri:noRegion>University Hospital Freiburg</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Newberg, Andrew" sort="Newberg, Andrew" uniqKey="Newberg A" first="Andrew" last="Newberg">Andrew Newberg</name>
<affiliation wicri:level="2">
<nlm:affiliation>Myrna Brind Center of Integrative Medicine, Thomas Jefferson University and Hospital, Philadelphia, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Myrna Brind Center of Integrative Medicine, Thomas Jefferson University and Hospital, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Frederiksen, Kristian S" sort="Frederiksen, Kristian S" uniqKey="Frederiksen K" first="Kristian S" last="Frederiksen">Kristian S. Frederiksen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Danish Dementia Research Center, Department of Neurology, Righospitalet, University of Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Danish Dementia Research Center, Department of Neurology, Righospitalet, University of Copenhagen</wicri:regionArea>
<wicri:noRegion>University of Copenhagen</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Fleisher, Adam S" sort="Fleisher, Adam S" uniqKey="Fleisher A" first="Adam S" last="Fleisher">Adam S. Fleisher</name>
<affiliation wicri:level="2">
<nlm:affiliation>The Banner Alzheimer's Institute, Phoenix, Arizona.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Arizona</region>
</placeName>
<wicri:cityArea>The Banner Alzheimer's Institute, Phoenix</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Mintun, Mark A" sort="Mintun, Mark A" uniqKey="Mintun M" first="Mark A" last="Mintun">Mark A. Mintun</name>
<affiliation wicri:level="2">
<nlm:affiliation>Avid Radiopharmaceuticals, Philadelphia, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Avid Radiopharmaceuticals, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Wolk, David A" sort="Wolk, David A" uniqKey="Wolk D" first="David A" last="Wolk">David A. Wolk</name>
<affiliation wicri:level="2">
<nlm:affiliation>Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Nordberg, Agneta" sort="Nordberg, Agneta" uniqKey="Nordberg A" first="Agneta" last="Nordberg">Agneta Nordberg</name>
<affiliation wicri:level="3">
<nlm:affiliation>Center for Alzheimer Research, Translational Alzheimer Neurobiology, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Center for Alzheimer Research, Translational Alzheimer Neurobiology, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName>
<settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O" last="Rinne">Juha O. Rinne</name>
<affiliation wicri:level="4">
<nlm:affiliation>Turku PET Centre and Division of Clinical Neuroscience, Turku University Hospital, University of Turku, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Turku PET Centre and Division of Clinical Neuroscience, Turku University Hospital, University of Turku</wicri:regionArea>
<placeName>
<settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
<orgName type="university">Université de Turku</orgName>
</affiliation>
</author>
<author>
<name sortKey="Chetelat, Gael" sort="Chetelat, Gael" uniqKey="Chetelat G" first="Gaël" last="Chételat">Gaël Chételat</name>
<affiliation wicri:level="3">
<nlm:affiliation>Institut National de la Santé et de la Recherche Medicale, Caen, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Santé et de la Recherche Medicale, Caen</wicri:regionArea>
<placeName>
<region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lleo, Alberto" sort="Lleo, Alberto" uniqKey="Lleo A" first="Alberto" last="Lleo">Alberto Lleo</name>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Neurology, Universitat Autònoma de Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Neurology, Universitat Autònoma de Barcelona</wicri:regionArea>
<placeName>
<settlement type="city">Barcelone</settlement>
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<nlm:affiliation>Center for Longevity, The University of Texas at Dallas.</nlm:affiliation>
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<author>
<name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J" last="Brooks">David J. Brooks</name>
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<nlm:affiliation>University of Texas Southwestern Medical Center, Dallas39Division of Neuroscience and Medical Research Council Clinical Sciences Centre, Imperial College London, United Kingdom.</nlm:affiliation>
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<title level="j">JAMA</title>
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<term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Amyloid beta-Peptides (analysis)</term>
<term>Apolipoprotein E4 (genetics)</term>
<term>Brain (pathology)</term>
<term>Dementia (pathology)</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Positron-Emission Tomography</term>
<term>Prevalence</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Apolipoprotéine E4 (génétique)</term>
<term>Démence (anatomopathologie)</term>
<term>Encéphale (anatomopathologie)</term>
<term>Facteurs de l'âge</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Mâle</term>
<term>Peptides bêta-amyloïdes (analyse)</term>
<term>Prévalence</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tomographie par émission de positons</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en">
<term>Amyloid beta-Peptides</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en">
<term>Apolipoprotein E4</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr">
<term>Peptides bêta-amyloïdes</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr">
<term>Démence</term>
<term>Encéphale</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr">
<term>Apolipoprotéine E4</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Brain</term>
<term>Dementia</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Positron-Emission Tomography</term>
<term>Prevalence</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
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<term>Adulte d'âge moyen</term>
<term>Facteurs de l'âge</term>
<term>Facteurs de risque</term>
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<term>Génotype</term>
<term>Humains</term>
<term>Mâle</term>
<term>Prévalence</term>
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<front>
<div type="abstract" xml:lang="en">Amyloid-β positron emission tomography (PET) imaging allows in vivo detection of fibrillar plaques, a core neuropathological feature of Alzheimer disease (AD). Its diagnostic utility is still unclear because amyloid plaques also occur in patients with non-AD dementia.</div>
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